I use Fedora with GNOME for my parents and other family members. Some have used Windows prior, some have not used computers at all really, only iPads. They all get along very well on GNOME!
I have started using Silverblue the last year, which simplify things even further. Combined with the excellent remote controll functionality, it has been a really pleasant experience both for me and them.
RDP has been the default on Fedora since version 40 (or was it 41?) and it has been a true joy to use! Remoting in to help family and friends has been as simple as set and forget, and very secure since I use it via my VPN (no public endpoint).
I use Remmina to connect though, not GNOME connect, as Remmina is more configurable.